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Study Participants

Who joined the PrecISE asthma study:

Qualifications: These are a few examples of criteria that will apply. Are age 12 and up; have severe asthma as defined by commonly accepted guidelines; Currently have uncontrolled asthma, or worsening asthma & attacks; Are on a stable regimen of asthma medications; are not pregnant and not breastfeeding; are not taking part in other clinical trialsPrecISE study centers recruited 304 adults and 28 adolescents (ages 12 years and older), for a total of 332 participants from over 30 sites in the US. The study participants met the criteria for severe asthma that is not well-controlled or with frequent asthma attacks.

What participants will do in the PrecISE asthma study:

As a part of PrecISE research, participants will be assigned a treatment that targets their type of severe asthma. The type of severe asthma will be determined using biomarkers. Biomarkers are bits of information about someone based on data gathered from tests, including blood tests. The likelihood for a participant to receive a therapy will change based on new data that will be collected during the study. Adult participants in PrecISE research may receive at least three treatments, and up to five treatments. Adolescents may receive up to two treatments. 

How PrecISE is different from other studies in severe asthma:

PrecISE will research new treatments in groups of patients characterized by their bodies' specific disease pathways in order to research treatments for each group. PrecISE will include participants with severe asthma to research new treatments.

Why is PrecISE important?

Current asthma medicines often don’t work well for people who have severe asthma.

Even when taking these medicines, people with severe asthma often continue to have daily symptoms (difficulty breathing, wheezing, chest tightness) and a greater risk of asthma attacks.

What medicines are participants in PrecISE given?

The PrecISE Clinical Trial - Multiple treatments will be tested in a placebo controlled randomized trial. Each participant will receive between 1 and 5 treatments, depending on age and enrollment date. Treatment periods will each last 16 weeks, requiring monthly visits. If they choose, participants can receive study provided baseline asthma therapies and asthma controller medications. Participants are assigned a treatment for their specific type of severe asthma, though the medications change during the study.

Adults in the PrecISE study will receive between 2 and 5 different treatments over the course of the study. Adolescents will receive up to 2 different treatments.

What participants in PrecISE will be asked to do:

- Answer questions about their medical history, asthma symptoms, and quality of life

- Receive physical exams, blood and urine tests, breathing tests, and a chest CT scan 

- Complete tasks at home (e-diary, home breathing tests)

Why do people participate in research studies?

- Although there is no guarantee, participants may benefit from the study treatment and/or information gained from study tests.

- All study tests and exams in the PrecISE study, including asthma medications, are provided at no charge.

- Research findings based on this study may lead to better ways of treating people with severe asthma.

Taking part in the PrecISE Study is voluntary. Participants are compensated for their time and may withdraw from the study at any time.

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